Throughout the world, different religious and spiritual traditions have used hallucinogenic drugs to enhance the mystical experience. These drugs can trigger the experience of flying or floating. In Southern California, many tribes traditionally used jimsonweed (a part of the nightshade family Datura, also known as toloache and datura) to help produce visions. Most frequently this was used during the initiation of boys into full manhood. During this time the initiates would drink an infusion made from jimsonweed root. The visions received at this time would guide people for the rest of their lives. In recognizing the spiritual power of jimsonweed, the tribes also knew that the plant could be deadly if used incorrectly and thus it was used only in ceremonial context and administered by knowledgeable elders. Even with these cautions, there were occasional deaths from using the plant.
Briefly described below are some of ceremonial uses of jimsonweed by California tribes.